Empiriko Biomimiks™

Our Biomimiks™ technology is designed around sterically protected and electronically activated tetra-azamacrocycles that function as synthetic livers and generate metabolites more amenable to isolation, characterization and pharmacological testing.

Biomimiks™ are used to:
  • Prepare isolable quantities of drug metabolites in non-aqueous conditions; synthesize on multi-gram scale
  • Correlate isolated metabolites with those obtained from clinically isolated phenotypes
  • Design an efficient method for the systematic preparation and identification of the entire spectrum of metabolites from a chosen drug
  • Detect pharmaceutical products and their metabolites from serum, blood and urine

The systematic preparation and identification of the entire spectrum of in vivo metabolites from a target drug requires several biomimetic systems which are built using different permutations of azamacrocycle, co-oxidants and a suitable solvent.