Our Biomimiks™ technology is designed around sterically protected and electronically activated tetra-azamacrocycles that function as synthetic livers and generate metabolites more amenable to isolation, characterization and pharmacological testing.Biomimiks™ are used to:
- Prepare isolable quantities of drug metabolites in non-aqueous conditions; synthesize on multi-gram scale
- Correlate isolated metabolites with those obtained from clinically isolated phenotypes
- Design an efficient method for the systematic preparation and identification of the entire spectrum of metabolites from a chosen drug
- Detect pharmaceutical products and their metabolites from serum, blood and urine
The systematic preparation and identification of the entire spectrum of in vivo metabolites from a target drug requires several biomimetic systems which are built using different permutations of azamacrocycle, co-oxidants and a suitable solvent.