Functional Analysis & Screening Technologies (FAST) Congress, Boston, MA (November 17 - 19, 2014)
Conference Title: Organic Culture Models for Toxicology – In Vitro Tools for Modeling and Predicting Organ-Specific Toxicity
Conference Description: It is recognized that in vitro toxicology studies are complex. Organotypic culture models (OCMs)—tissue models that mimic in vivo tissue architecture through interactions of heterotypic cell types and extracellular matrices—are increasingly being explored for prediction of organ-specific toxicity. As these models become more widely used for chemical and drug toxicity testing, there is a corresponding need to establish standardized testing conditions, endpoint analyses and acceptance criteria. Cambridge Healthtech Institute’s Inaugural Organotypic Culture Models for Toxicology meeting addresses the balanced approach between sample throughput and biological relevance, providing better in vitro tools to replace animal testing and predict human risk assessment.
Empiriko Presentation: Biomimiks as Chemosynthetic Livers: Mukund S. Chorghade, Ph.D., CSO, Empiriko Corporation
Our proprietary technology mimics metabolism of chemical entities for pharmaceuticals, enables prediction of metabolism patterns and introduces new paradigms for drug discovery and drug-drug interactions. Our catalysts provide speed, stability and scalability. We predict structures of metabolites, prepare them on scale and elucidate chemical structures. Comprehensive safety evaluation enables complete metabolism studies, confirmation of structure and quantitative measures of toxicity. This is an animal-free platform for safety-relevant metabolites.